Private Event
Hot Topics in Computing-Manolis Kellis: Reversing Human Disease Circuitry
Speaker
Manolis Kellis
CSAIL MIT
Host
Daniela Rus
MIT SCC & CSAIL
Abstract:
Humanity is at a crossroads, where an aging population is confronting many new diseases, while genomics and machine learning advances are providing unprecedented opportunity for rewiring our cells to combat disease and aging. I will first describe recent advances in our lab for understanding the circuitry of Alzheimer's, obesity, heart disease, and psychiatric disorders at single cell resolution, and the steps we are taking for systematic manipulation of these circuits through high throughput experimentation and synthesis. I will then describe a vision for transforming clinical trials to enable precision medicine and personalized medicine, by focusing on the pathways and hallmarks underlying disease, and how they manifest at the genetic, epigenomic, transcriptional, and circuit level in each individual, and the resources that we need to put in place to enable this transformation across many sectors of science, technology, and finance. The goal of the evening is to use my comments for discussion, and to think how MIT, CSAIL, and our partners in hospitals, pharma, and biotechnology can work together to transform medicine and human health.
This is a hybrid event held on campus in Stata Center, Star Seminar Room 32-D463, and via Zoom (see invitation email for Zoom details or contact events@csail.mit.edu)
Humanity is at a crossroads, where an aging population is confronting many new diseases, while genomics and machine learning advances are providing unprecedented opportunity for rewiring our cells to combat disease and aging. I will first describe recent advances in our lab for understanding the circuitry of Alzheimer's, obesity, heart disease, and psychiatric disorders at single cell resolution, and the steps we are taking for systematic manipulation of these circuits through high throughput experimentation and synthesis. I will then describe a vision for transforming clinical trials to enable precision medicine and personalized medicine, by focusing on the pathways and hallmarks underlying disease, and how they manifest at the genetic, epigenomic, transcriptional, and circuit level in each individual, and the resources that we need to put in place to enable this transformation across many sectors of science, technology, and finance. The goal of the evening is to use my comments for discussion, and to think how MIT, CSAIL, and our partners in hospitals, pharma, and biotechnology can work together to transform medicine and human health.
This is a hybrid event held on campus in Stata Center, Star Seminar Room 32-D463, and via Zoom (see invitation email for Zoom details or contact events@csail.mit.edu)