Boltz: Towards a Unified Approach for Biomolecular Interaction Modeling

7:00 PM, Tuesday, 24 June 2025

MIT Room 32-G449 (Kiva) and online via Zoom

Boltz: Towards a Unified Approach for Biomolecular Interaction Modeling

Gabriele Corso and Jeremy Wohlwend

Please register in advance for this seminar even if you plan to attend in person at

https://acm-org.zoom.us/webinar/register/9317463194385/WN_U1yhFblMQO-I4n1cBhkBFw

After registering, you will receive a confirmation email containing information about joining the webinar.

Indicate on the registration form if you plan to attend in person.  This will help us determine whether the room is close to reaching capacity. We plan to serve light refreshments (probably pizza) before
the talk starting at around 6:30 pm. Letting us know you will come in person will help us determine how much pizza to order.                

We may make some auxiliary material such as slides and access to the recording available after the seminar to people who have registered.

Abstract:

Understanding biomolecular interactions is fundamental to advancing fields like drug discovery and protein design. In this talk, we introduce Boltz-1, an open-source deep learning model incorporating
innovations in model architecture, speed optimization, and data processing achieving AlphaFold3-level accuracy in predicting the 3D structures of biomolecular complexes. Boltz-1 demonstrates a
performance on-par with state-of-the-art commercial models on a range of diverse benchmarks, setting a new benchmark for commercially accessible tools in structural biology. By releasing the training and
inference code, model weights, datasets, and benchmarks under the MIT open license, we aim to foster global collaboration, accelerate discoveries, and provide a robust platform for advancing biomolecular
modeling.

Bio: Jeremy Wohlwend and Gabriele Corso are PhD students at the MIT Computer Science and Artificial Intelligence Laboratory where their research focuses on developing novel ML frameworks to tackle
challenging problems in drug discovery and immunology.

Directions to 32-G449 - MIT Stata Center, 32 Vassar Street, Cambridge, MA: Please use the main entrance to the Stata Center at 32 Vassar Street (the entrance closest to Main street) as those doors will be
unlocked. Upon entering, proceed to the elevators which will be on the right after passing a large set of stairs and a MITAC kiosk. Take the elevator to the 4th floor and turn right, following the hall to an
open area; 32-G449 will be on the left. Location of Stata on campus map.

This joint meeting of the Boston Chapter of the IEEE Computer and EMBS Societies and GBC/ACM will be hybrid (in person and online).

Up-to-date information about this and other talks is available online at https://ewh.ieee.org/r1/boston/computer/. You can sign up to receive updated status information about this talk and informational
emails about future talks at https://mailman.mit.edu/mailman/listinfo/ieee-cs, our self-administered mailing list.