This CoR brings together researchers at CSAIL working across a broad swath of application domains. Within these lie novel and challenging machine learning problems serving science, social science and computer science.
This community is interested in understanding and affecting the interaction between computing systems and society through engineering, computer science and public policy research, education, and public engagement.
In order to be able to design synthetic organs that function autonomously, we will need to engineer artificial tissue homeostasis. To control the size of these artificial tissues, two major mechanisms will have to be engineered.
Automatic speech recognition (ASR) has been a grand challenge machine learning problem for decades. Our ongoing research in this area examines the use of deep learning models for distant and noisy recording conditions, multilingual, and low-resource scenarios.
Existing methods for cloning and recombination of DNA enable construction of arbitrary sequences. However, the sequential nature of these techniques makes them time-consuming and expensive. Furthermore, while the transformation of an existing plasmid into a host strain can be reliable when a selection marker is used, there are many current limitations: the number of different plasmids that can be co-transformed is limited by the choice of markers and compatible origins of replication; plasmids are less stable than chromosomal DNA and are difficult to maintain indefinitely without mutation; and cistronic interactions cannot be designed since each new nucleotide sequence added is on an unconnected DNA molecule. To overcome these limitations, we are designing reconfigurable chromosomes consisting of both fixed and variable regions. While the fixed region is carefully optimized and tuned ahead of time, the variable region can be modified in the field, at the point-of-use, leading to rapid and on-demand realization of novel biocircuits with many different phenotypes.
A "precision medicine" approach for finding relevant cancer treatments in clinical literature and eligible trials. For a given patient with associated demographics (age, gender) and disease (cancer type, genetic variants), we query a database of all pubmed articles and clinicaltrials.gov trials using NLP techniques to find the most useful and relevant treatments for the patient. Our ensemble-based system performed very well in the TREC 2016 Precision Medicine challenge.
We develop, parameterize, and validate a model for tumor growth inhibition using in vivo mouse data and study the effects of modeling uncertainty and inter-individual variability on drug candidate efficacy predictions.
Google AI’s Jeff Dean has a seemingly straightforward objective: he wants to use a collection of trainable mathematical units organized in layers to solve complicated tasks that will ultimately benefit many parts of society.
This week it was announced that MIT professors and CSAIL principal investigators Shafi Goldwasser, Silvio Micali, Ronald Rivest, and former MIT professor Adi Shamir won this year’s BBVA Foundation Frontiers of Knowledge Awards in the Information and Communication Technologies category for their work in cryptography.
This week it was announced that MIT professor and CSAIL principal investigator Regina Barzilay was named an Association for the Advancement of Artificial Intelligence (AAAI) Fellow for her research contributions to the field of artificial intelligence (AI).
Neural networks, which learn to perform computational tasks by analyzing huge sets of training data, have been responsible for the most impressive recent advances in artificial intelligence, including speech-recognition and automatic-translation systems.
Every year 40,000 women die from breast cancer in the U.S. alone. When cancers are found early, they can often be cured. Mammograms are the best test available, but they’re still imperfect and often result in false positive results that can lead to unnecessary biopsies and surgeries.
Doctors are often deluged by signals from charts, test results, and other metrics to keep track of. It can be difficult to integrate and monitor all of these data for multiple patients while making real-time treatment decisions, especially when data is documented inconsistently across hospitals. In a new pair of papers, researchers from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) explore ways for computers to help doctors make better medical decisions.
When organic chemists identify a useful chemical compound — a new drug, for instance — it’s up to chemical engineers to determine how to mass-produce it. There could be 100 different sequences of reactions that yield the same end product. But some of them use cheaper reagents and lower temperatures than others, and perhaps most importantly, some are much easier to run continuously, with technicians occasionally topping up reagents in different reaction chambers.
Laparoscopy is a surgical technique in which a fiber-optic camera is inserted into a patient’s abdominal cavity to provide a video feed that guides the surgeon through a minimally invasive procedure. Laparoscopic surgeries can take hours, and the video generated by the camera — the laparoscope — is often recorded. Those recordings contain a wealth of information that could be useful for training both medical providers and computer systems that would aid with surgery, but because reviewing them is so time consuming, they mostly sit idle.
In experiments involving a simulation of the human esophagus and stomach, researchers at CSAIL, the University of Sheffield, and the Tokyo Institute of Technology have demonstrated a tiny origami robot that can unfold itself from a swallowed capsule and, steered by external magnetic fields, crawl across the stomach wall to remove a swallowed button battery or patch a wound.The new work, which the researchers are presenting this week at the International Conference on Robotics and Automation, builds on a long sequence of papers on origami robots from the research group of CSAIL Director Daniela Rus, the Andrew and Erna Viterbi Professor in MIT’s Department of Electrical Engineering and Computer Science.
For people struggling with obesity, logging calorie counts and other nutritional information at every meal is a proven way to lose weight. The technique does require consistency and accuracy, however, and when it fails, it’s usually because people don't have the time to find and record all the information they need.A few years ago, a team of nutritionists from Tufts University who had been experimenting with mobile-phone apps for recording caloric intake approached members of the Spoken Language Systems Group at MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL), with the idea of a spoken-language application that would make meal logging even easier.
In the last 10 years, it’s become far more common for physicians to keep records electronically. Those records could contain a wealth of medically useful data: hidden correlations between symptoms, treatments and outcomes, for instance, or indications that patients are promising candidates for trials of new drugs.