This CoR brings together researchers at CSAIL working across a broad swath of application domains. Within these lie novel and challenging machine learning problems serving science, social science and computer science.
This community is interested in understanding and affecting the interaction between computing systems and society through engineering, computer science and public policy research, education, and public engagement.
In order to be able to design synthetic organs that function autonomously, we will need to engineer artificial tissue homeostasis. To control the size of these artificial tissues, two major mechanisms will have to be engineered.
Automatic speech recognition (ASR) has been a grand challenge machine learning problem for decades. Our ongoing research in this area examines the use of deep learning models for distant and noisy recording conditions, multilingual, and low-resource scenarios.
Existing methods for cloning and recombination of DNA enable construction of arbitrary sequences. However, the sequential nature of these techniques makes them time-consuming and expensive. Furthermore, while the transformation of an existing plasmid into a host strain can be reliable when a selection marker is used, there are many current limitations: the number of different plasmids that can be co-transformed is limited by the choice of markers and compatible origins of replication; plasmids are less stable than chromosomal DNA and are difficult to maintain indefinitely without mutation; and cistronic interactions cannot be designed since each new nucleotide sequence added is on an unconnected DNA molecule. To overcome these limitations, we are designing reconfigurable chromosomes consisting of both fixed and variable regions. While the fixed region is carefully optimized and tuned ahead of time, the variable region can be modified in the field, at the point-of-use, leading to rapid and on-demand realization of novel biocircuits with many different phenotypes.
We develop, parameterize, and validate a model for tumor growth inhibition using in vivo mouse data and study the effects of modeling uncertainty and inter-individual variability on drug candidate efficacy predictions.
We develop algorithms, systems and software architectures for automating reconstruction of accurate representations of neural tissue structures, such as nanometer-scale neurons' morphology and synaptic connections in the mammalian cortex.
We aim to develop a context-aware data-driven functional genomics framework that can characterize tissue-specific gene representations, provide context-aware genotype to phenotype mapping, and enable network-based exploration of disease genetics.
All humans process vast quantities of unannotated speech and manage to learn phonetic inventories, word boundaries, etc., and can use these abilities to acquire new word. Why can't ASR technology have similar capabilities? Our goal in this research project is to build speech technology using unannotated speech corpora.
This week it was announced that MIT professors and CSAIL principal investigators Shafi Goldwasser, Silvio Micali, Ronald Rivest, and former MIT professor Adi Shamir won this year’s BBVA Foundation Frontiers of Knowledge Awards in the Information and Communication Technologies category for their work in cryptography.
Neural networks, which learn to perform computational tasks by analyzing huge sets of training data, have been responsible for the most impressive recent advances in artificial intelligence, including speech-recognition and automatic-translation systems.
When organic chemists identify a useful chemical compound — a new drug, for instance — it’s up to chemical engineers to determine how to mass-produce it. There could be 100 different sequences of reactions that yield the same end product. But some of them use cheaper reagents and lower temperatures than others, and perhaps most importantly, some are much easier to run continuously, with technicians occasionally topping up reagents in different reaction chambers.
In experiments involving a simulation of the human esophagus and stomach, researchers at CSAIL, the University of Sheffield, and the Tokyo Institute of Technology have demonstrated a tiny origami robot that can unfold itself from a swallowed capsule and, steered by external magnetic fields, crawl across the stomach wall to remove a swallowed button battery or patch a wound.The new work, which the researchers are presenting this week at the International Conference on Robotics and Automation, builds on a long sequence of papers on origami robots from the research group of CSAIL Director Daniela Rus, the Andrew and Erna Viterbi Professor in MIT’s Department of Electrical Engineering and Computer Science.
For people struggling with obesity, logging calorie counts and other nutritional information at every meal is a proven way to lose weight. The technique does require consistency and accuracy, however, and when it fails, it’s usually because people don't have the time to find and record all the information they need.A few years ago, a team of nutritionists from Tufts University who had been experimenting with mobile-phone apps for recording caloric intake approached members of the Spoken Language Systems Group at MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL), with the idea of a spoken-language application that would make meal logging even easier.