Research

Robot scheduling via learning from demonstration for tasks in medicine and more

Our goal is to develop a socially intelligent team coacher agent that helps humans communicate, strategize, and work together efficiently.

In order to be able to design synthetic organs that function autonomously, we will need to engineer artificial tissue homeostasis. To control the size of these artificial tissues, two major mechanisms will have to be engineered.

Integrating multi-modal clinical data and using recurrent and convolution neural networks to predict when patients will need important interventions.

We use computational models of biological pathways in disease to estimate the range of possible responses to various hypothetical drugs, given patient variability and limited pathway-relevant data.

Existing methods for cloning and recombination of DNA enable construction of arbitrary sequences. However, the sequential nature of these techniques makes them time-consuming and expensive. Furthermore, while the transformation of an existing plasmid into a host strain can be reliable when a selection marker is used, there are many current limitations: the number of different plasmids that can be co-transformed is limited by the choice of markers and compatible origins of replication; plasmids are less stable than chromosomal DNA and are difficult to maintain indefinitely without mutation; and cistronic interactions cannot be designed since each new nucleotide sequence added is on an unconnected DNA molecule. To overcome these limitations, we are designing reconfigurable chromosomes consisting of both fixed and variable regions. While the fixed region is carefully optimized and tuned ahead of time, the variable region can be modified in the field, at the point-of-use, leading to rapid and on-demand realization of novel biocircuits with many different phenotypes.

Developing state-of-the-art tools that process 3D surfaces and volumes

We aim to study the causes and transmission modes of infectious diseases among members of a community in the presence of hidden, asymptomatic spreaders of the pathogen.

Models and algorithms to predict in real time the next actions of a human working together with a robot

Our goal is to develop better metagenomic binning by origin species of fragments of sequenced environmental DNA.

We develop, parameterize, and validate a model for tumor growth inhibition using in vivo mouse data and study the effects of modeling uncertainty and inter-individual variability on drug candidate efficacy predictions.

Transitioning machine learning models across electronic health record (EHR) versions can be improved by mapping different EHR encodings to a common vocabulary.

We are developing a general framework that enforces privacy transparently enabling different kinds of machine learning to be developed that are automatically privacy preserving.

We develop algorithms, systems and software architectures for automating reconstruction of accurate representations of neural tissue structures, such as nanometer-scale neurons' morphology and synaptic connections in the mammalian cortex.

Our goal is to develop algorithms for allowing robots to adapt intelligently to humans when they are working together as a team.

Using adversarial signals and a cycle-consistency based regularization, we can supplement paired regression tasks with unpaired data to improve regression performance.

Putting a twist on traditional pneumatic soft robots via handed shearing auxetics

This project uses computational biology and chemistry tools to design a pharmaceutical to combat the Zika Virus.

What if we could control robots more intuitively, using just hand gestures and brainwaves?

We aim to develop a context-aware data-driven functional genomics framework that can characterize tissue-specific gene representations, provide context-aware genotype to phenotype mapping, and enable network-based exploration of disease genetics.

Uhura is an autonomous system that collaborates with humans in planning and executing complex tasks, especially under over-subscribed and risky situations.

Using medical knowledge to improve learned representations of patient health trajectories.

We enable independent navigation for visually impaired users through a wearable feedback system using time-of-light sensors or depth cameras.

The goal of this project is to develop and test a wearable ultrasonic echolocation aid for people who are blind and visually impaired. We combine concepts from engineering, acoustic physics, and neuroscience to make echolocation accessible as a research tool and mobility aid.