This CoR brings together researchers at CSAIL working across a broad swath of application domains. Within these lie novel and challenging machine learning problems serving science, social science and computer science.
This community is interested in understanding and affecting the interaction between computing systems and society through engineering, computer science and public policy research, education, and public engagement.
We build new protocols and architectures to improve the robustness and performance of computer networks. We develop practical solutions in wireless networks, network security, traffic engineering, congestion control, and routing.
The Systems CoR is focused on building and investigating large-scale software systems that power modern computers, phones, data centers, and networks, including operating systems, the Internet, wireless networks, databases, and other software infrastructure.
In order to be able to design synthetic organs that function autonomously, we will need to engineer artificial tissue homeostasis. To control the size of these artificial tissues, two major mechanisms will have to be engineered.
Existing methods for cloning and recombination of DNA enable construction of arbitrary sequences. However, the sequential nature of these techniques makes them time-consuming and expensive. Furthermore, while the transformation of an existing plasmid into a host strain can be reliable when a selection marker is used, there are many current limitations: the number of different plasmids that can be co-transformed is limited by the choice of markers and compatible origins of replication; plasmids are less stable than chromosomal DNA and are difficult to maintain indefinitely without mutation; and cistronic interactions cannot be designed since each new nucleotide sequence added is on an unconnected DNA molecule. To overcome these limitations, we are designing reconfigurable chromosomes consisting of both fixed and variable regions. While the fixed region is carefully optimized and tuned ahead of time, the variable region can be modified in the field, at the point-of-use, leading to rapid and on-demand realization of novel biocircuits with many different phenotypes.
We develop, parameterize, and validate a model for tumor growth inhibition using in vivo mouse data and study the effects of modeling uncertainty and inter-individual variability on drug candidate efficacy predictions.
We develop algorithms, systems and software architectures for automating reconstruction of accurate representations of neural tissue structures, such as nanometer-scale neurons' morphology and synaptic connections in the mammalian cortex.
We aim to develop a context-aware data-driven functional genomics framework that can characterize tissue-specific gene representations, provide context-aware genotype to phenotype mapping, and enable network-based exploration of disease genetics.
Last week MIT’s Institute for Foundations of Data Science (MIFODS) held an interdisciplinary workshop aimed at tackling the underlying theory behind deep learning. Led by MIT professor Aleksander Madry, the event focused on a number of research discussions at the intersection of math, statistics, and theoretical computer science.
MIT’s Amar Gupta and his wife Poonam were on a trip to Los Angeles in 2016 when she fell and broke both wrists. She was whisked by ambulance to a reputable hospital. But staff informed the couple that they couldn’t treat her there, nor could they find another local hospital that would do so. In the end, the couple was forced to take the hospital’s stunning advice: return to Boston for treatment.
This week it was announced that MIT professors and CSAIL principal investigators Shafi Goldwasser, Silvio Micali, Ronald Rivest, and former MIT professor Adi Shamir won this year’s BBVA Foundation Frontiers of Knowledge Awards in the Information and Communication Technologies category for their work in cryptography.
Artificial intelligence (AI) in the form of “neural networks” are increasingly used in technologies like self-driving cars to be able to see and recognize objects. Such systems could even help with tasks like identifying explosives in airport security lines.
Doctors are often deluged by signals from charts, test results, and other metrics to keep track of. It can be difficult to integrate and monitor all of these data for multiple patients while making real-time treatment decisions, especially when data is documented inconsistently across hospitals. In a new pair of papers, researchers from MIT’s Computer Science and Artificial Intelligence Laboratory (CSAIL) explore ways for computers to help doctors make better medical decisions.
When organic chemists identify a useful chemical compound — a new drug, for instance — it’s up to chemical engineers to determine how to mass-produce it. There could be 100 different sequences of reactions that yield the same end product. But some of them use cheaper reagents and lower temperatures than others, and perhaps most importantly, some are much easier to run continuously, with technicians occasionally topping up reagents in different reaction chambers.
A webpage today is often the sum of many different components. A user’s home page on a social-networking site, for instance, might display the latest posts from the users’ friends; the associated images, links, and comments; notifications of pending messages and comments on the user’s own posts; a list of events; a list of topics currently driving online discussions; a list of games, some of which are flagged to indicate that it’s the user’s turn; and of course the all-important ads, which the site depends on for revenues.