Biography
We are interested in conformational changes in macromolecules and the effect of structural transitions on common human diseases. Since conformational transitions in biomolecules are typically difficult to observe experimentally, we use novel methods to gain insights into the role that molecular structure plays in the progression of human disease. We employ an interdisciplinary approach that utilizes techniques drawn from computational chemistry, signal processing, and basic biochemistry.
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Publications
- Collin M. Stultz, James V. White, Temple F. Smith. Structural Analysis Based on State Space Modeling. Protein Science 1993; 2:305-314
- James V. White, Collin M. Stultz, Temple F. Smith. Protein Classification by Stochastic Modeling and Optimal Filtering of Amino-Acid Sequences. Mathematical Biosciences 1994; 119:35-75
- Collin M. Stultz and Martin Karplus. On the Potential Surface of the Locally Enhanced Sampling Approximation. Journal of Chemical Physics 1998; 109: 8809-8815
- Collin M. Stultz and Martin Karplus. MCSS Functionality Maps for a Flexible Protein. Proteins, Structure Function and Gentetics. 1999; 37:512-529
- Collin M. Stultz and Martin Karplus. Dynamic Ligand Design and Combinatorial Optimization. Proteins, Structure Function and Genetics 2000; 40:259-289
- Collin M. Stultz, Localized Unfolding of Collagen Explains Collagenase Cleavage Near Imino-Poor Sites. J. Mol. Biol. 2002; 319: 997-1003
- Collin M. Stultz, Andrew D. Levin, Elazer R. Edelman. Phosphorylation Induced Conformational Changes in a MAP-Kinase Substrate: Implications for Tyrosine Hydroxylase Activation. J. Biol. Chem. 2002; 277: 47653-47661
- Collin M. Stultz, Elazer R. Edelman. A Structural Model that Explains the Effects of Hyperglycemia on Collagenolysis. Biophys. J. 2003; 85: 2198-2204
- Collin M. Stultz, An Assessment of Potential of Mean Force Calculations with Implicit Solvent Models. J. Chem. Phys B 2004, 108:16525-16532.
Awards- Burroughs Wellcome Fund: Career Award in the Biomedical Sciences
- Harvard Medical School: James Tolbert Shipley Prize
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