Mapping the protein space: From novel system topologies to semantically significant domain architectures and functional maps of the protein space.
Speaker: Golan Yona , Dept of CS, Technion, IsraelContact:
Date: October 17 2005
Time: 11:30AM to 1:00PM
Location: 32-G575 TOC Lab
Host: P Clote/ BC & B Berger/ MIT
Kathleen Dickey, 617 253 3037, firstname.lastname@example.orgRelevant URL: http://www-math.mit.edu/compbiosem/
In this talk I will present some of the elements that make up our long-term project to chart the protein space.
In the first part of the talk I will present Biozon (biozon.org). an extensive knowledge resource of heterogeneous biological data that holds more than 100 million biological documents and 6.5 billion relations. Biozon supports complex and fuzzy searches and also integrates first-of-a-kind biological ranking system which resembles the methods implemented in Google.
The rest of the talk will be devoted to the algorithms and models that we have developed for detection of domains and semantically significant domain architectures, new similarity measures between proteins and protein families, and novel embedding techniques that we have developed and are used to construct a complete "road map" of the protein universe.
For more information see http://biozon.org and http://www.cs.cornell.edu/golan
The seminar is co-hosted by Professor Peter Clote of Boston College's Biology and Computer Science Departments and MIT Professor of Applied Math Bonnie Berger. Professor Berger is also affiliated with CSAIL & HST.
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