The tale of two protein domain problems...

Speaker: Temple Smith , Boston University
Date: April 12 2004
Time: 11:30AM to 12:45AM
Location: 2-338
Host: P Clote, BC & B Berger, MIT/CSAIL
Contact: Kathleen Dickey, 617 253 3037, kvdickey@mit.edu
Relevant URL: http://www-math.mit.edu/compbiosem/
"The tale of two protein domain problems,
1) Novel HMM dissection,
2) Very early evolution."
Abstract:
The first tale is of a modified form of 'designed' Hidden Markov Models
for multi-domain proteins to identify the domain fold classes and their
probable boundaries. While the second tale is of a combination
of multi-alignment, profile and statistical approaches to identify
'signature' protein domains or blocks that suggest a major
evolutionary event nearly 2.2 Gyrs ago.
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