Comparison of Diffusion and Transport in Human Head
Speaker: Anna Custo , CSAIL
Date: December 9 2003
Time: 4:00pm
Location: NE43 8th floor playroom
Diffuse Optical Imaging (DOI) is a relatively new method used to image blood volume and oxygen saturation in vivo. It uses near infrared light and has the advantage of low cost and portability.
In this work we study brain activation. An accurate measure of relative Cerebral Metabolic Rate of Oxygen (rCMRO2) provides relevant information about neuron activation. rCMRO2 is synthesized from a complete set of hemodynamic parameters such as oxygenated hemoglobin (HbO), deoxygenated hemoglobin (Hbr), cerebral blood flow (CBF) and cerebral blood volume (CBV).
MRI provides structural information that can be integrated with DOT data (characterized by high temporal resolution) to generate more reliable and accurate data. fMRI strength in measuring CBF can be coupled with DOT accuracy in calculating CBV and Hbr for a complete set of hemodynamic parameters.
The aim of this preliminary work is to test the accuracy of Diffusion Approximation implemented in the Finite Difference (FD) algorithm against Monte Carlo predictions of absorption coefficient changes.
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