CSAIL Event Calendar: Previous Series

Matching Patients to Therapies: Markers, Models & Medications

Speaker: Zeeshan Syed , University of Michigan
Date: February 27 2012
Time: 4:00PM to 5:00PM
Location: 32-G449
Host: Bruce Tidor, EECS

Contact: Francis Doughty, 253-4602, doughty@mit.edu

In 2010, an estimated 1.25 million coronary attacks occurred in the United States, causing nearly 1 of every 6 deaths. This burden is similar in most of the developed world, and increasingly in the developing world as well. While many useful therapies exist for cardiac patients, the question of how to productively match therapies to patients is not well understood. Therapies that would extend the life of one patient may be associated with an increased risk of mortality for others. In this talk, I will describe our work on addressing this situation through computational advances that improve our ability to understand and treat patients. I will focus, in particular, on the opportunities arising through computational research and physiological insights to develop new electrocardiographic biomarkers, improve models for cardiac prediction, and personalize patient treatments. I will present an evaluation of these ideas on data from two separate clinical studies with over 5,000 patients, and describe how this work can be leveraged for translational clinical impact.

Bio: Zeeshan Syed is an Assistant Professor of Electrical Engineering and Computer Science at the University of Michigan. His research interests focus on computational advances in diagnosing and treating major clinical disorders, both within the setting of modern medicine and developing world healthcare. Zeeshan received his S.B. and M.Eng. degrees in EECS from MIT, and his Ph.D. in Computer Science and Biomedical Engineering from the Harvard-MIT Division of Health Sciences and Technology. He is a recipient of a National Science Foundation Faculty Early Career (CAREER) award.

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