CSAIL Event Calendar: Previous Series
Matching Patients to Therapies: Markers, Models & Medications
Speaker: Zeeshan Syed , University of Michigan
In 2010, an estimated 1.25 million coronary attacks occurred in the United States, causing nearly 1 of every 6 deaths. This burden is similar in most of the developed world, and increasingly in the developing world as well. While many useful therapies exist for cardiac patients, the question of how to productively match therapies to patients is not well understood. Therapies that would extend the life of one patient may be associated with an increased risk of mortality for others. In this talk, I will describe our work on addressing this situation through computational advances that improve our ability to understand and treat patients. I will focus, in particular, on the opportunities arising through computational research and physiological insights to develop new electrocardiographic biomarkers, improve models for cardiac prediction, and personalize patient treatments. I will present an evaluation of these ideas on data from two separate clinical studies with over 5,000 patients, and describe how this work can be leveraged for translational clinical impact.