CSAIL Event Calendar: Previous Series

Medical image analysis to detect imaging biomarkers of neurological disorders: from perfusion imaging to stream lines analysis

Speaker: Christian Barillot , CNRS/INRIA Rennes, France
Date: December 2 2010
Time: 4:00PM to 5:00PM
Location: 32-D507
Host: Polina Golland, CSAIL

One of the major challenges in clinical neuroimaging is to detect quantitative signs of pathological evolution as early as possible in order to prevent disease progression, evalute therapeutic protcols or even better understand and model the normal history of a given neurological pathology. This presentation will give some illustrations of this challenge from two types of procedures: Arterial Spin Labeling and application of white matter fiber shape analysis in Multiple Sclerosis.

Many pathologies encompass brain alterations often not visible on conventional MRI sequences, especially in normal appearing brain tissues (NABT). MRI has often a low specificity for differentiating between possible pathological changes which could aid in discriminating between the different pathological stages or grades. The objective of medical image analysis procedures is to define new neuroimaging biomarkers to track the evolution of the pathology at a different level. This presentation will illustrate this issue at the metabolic level as well as at the white matter fibers level.

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