CSAIL Event Calendar: Previous Series
Oscillations in signal transduction: functional or accidental?
Speaker: Andre Levchenko , Johns Hopkins University
Relevant URL: http://www-math.mit.edu/compbiosem/
Recently, a number of signal transduction pathways have been shown to exhibit oscillatory behavior. However, as in many other biological oscillations, there is a chance the instability is just a by-product of adaptive behavior. Here, using the examples of the NF-kappaB and MAPK pathways in two different biological systems, I will demonstrate that the oscillatory response is essential for such essential cell functions as precise coordination of gene expression and cell morphology regulation. I will describe in detail the development of computational models of these two pathways as well as experimentally validated model predictions within the context of biological function.