CSAIL Event Calendar: Previous Series

Oscillations in signal transduction: functional or accidental?

Speaker: Andre Levchenko , Johns Hopkins University
Date: October 25 2004
Time: 11:30AM to 1:00PM
Location: TOC Lab at MIT, Stata Center, 32-G575
Host: P Clote/ BC & Bonnie Berger/ MIT- Math & CSAIL, Theory of Computation Lab at MIT's Building 32, St

Recently, a number of signal transduction pathways have been shown to exhibit oscillatory behavior. However, as in many other biological oscillations, there is a chance the instability is just a by-product of adaptive behavior. Here, using the examples of the NF-kappaB and MAPK pathways in two different biological systems, I will demonstrate that the oscillatory response is essential for such essential cell functions as precise coordination of gene expression and cell morphology regulation. I will describe in detail the development of computational models of these two pathways as well as experimentally validated model predictions within the context of biological function.

***: Support for the invitation of this speaker is generously provided by SERONO Reproductive Biology Institute in Boston (SRBI) , with special thanks to Dr. Jadwiga Bienkowska.

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