CSAIL Event Calendar: Previous Series
Systems Biomedicine and the Multi-Node Drug Target
Speaker: Joseph Lehár , CombinatoRx Incorporated, Cambridge MA USA
Relevant URL: http://www-math.mit.edu/compbiosem/
Systematic testing of chemical combinations in cell-based disease models can yield novel information on how proteins interact in a biological system, and thus can make important contributions to biological models of those diseases. Such combination screens can also preferentially discover synergies with beneficial therapeutic selectivity, especially when used in high-order mixtures of more than two agents. We will discuss numerical simulations and experimental results which establish the efficacy and selectivity of synergistic combinations in complex biological systems. These studies demonstrate the value obtainable from combination chemical genetics, and reinforce the growing realization that the most useful paradigm for a drug target is no longer a single molecule in a relevant pathway, but instead the set of targets that can cooperate to produce a therapeutic response with reduced side effects.