Motif Detection under RNA Structural Constraints
Speaker: Prof. Dr. Rolf Backofen , Lehrstuhl für Bioinformatik Institut für Informatik
Date: January 11 2008
Time: 3:00PM to 4:00PM
Location: Stata Center 32-G575
Host: Bonnie Berger & Peter Clote, MIT - BC
Contact: Patrice Macaluso, 617-723-8183, macaluso@csail.mit.edu
Relevant URL: In the past years, the common view of RNA has evolved from a more or less
boring intermediate in protein translation to a very important player
in cell regulation. The changed role was primarily the result of the detection of thousands of non-coding RNAs with many different regulatory functions in post-translational regulation.
The detection of new functional RNAs requires new comparative methods for motif detection since the RNA sequence is much less conserved than the RNA
structure. Hence, purely sequence-based methods for finding RNA-motifs such as multiple sequence alignment will fail, and we will discuss various approach (e.g. MARNA, LocaRNA) to sequence-structure
alignment developed in our group. Beside finding structural RNAs, we will also discuss the importance of the RNA secondary structure for the regulation of the binding efficiency of RNA-binding proteins like splice enhancers/silencers.
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