Mass Spectrometry and its modern evolution -- from Atomic Bomb to Proteomics and Beyond.
Speaker: Yi-Kuo Yu , NIH/NLM/NCBI
Date: May 9 2007
Time: 11:30AM to 1:00PM
Location: TOC lab 32-G575
Host: Bonnie Berger and Peter Clote, MIT/BC
Contact: Patrice Macaluso, 617-253-3037, macaluso@csail.mit.edu
Mass spectrometry is one of the most useful tools ever developed.
In the past century, we have witnessed its broad usability ranging from element
purification to application in biology.
In addition to a very brief historical reviews, I will mainly discuss
its use in proteomics and systems biology. Key problems in utilizing
mass spectrometry in these area such as sensitivity and statistical
accuracy will be described in particular. To address problems associated with
peptide identification confidence that is of immense importance in modern
proteomics, we have developed methods, RAId and RAId_DbS, aiming to solve
those problems.
Comparison of our methods to other existing tools in terms of peptide Identification and statistical accuracy will be shown.
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