Imaging the Brain in Health and Disease: Emerging Challenges and Opportunities for Computational Approaches
Speaker: Randy L Buckner , Harvard University
Date: September 7 2006
Time: 2:00PM to 3:00PM
Location: 32-D507
Host: Polina Golland, CSAIL
Contact: Polina Golland, x38005, polina@csail.mit.edu
Relevant URL: Human brain imaging methods apply an array of techniques to image the
structure and function of the living brain. The application of these methods
has grown rapidly over the past decade. Emerging with this growth are
significant data analysis challenges including the need to integrate
markedly different data types into common frameworks for comparison as well
as automation of data analysis to accommodate large-scale studies that link
genetic and brain data. In this presentation, I will discuss some of our
recent work on memory and Alzheimer's disease as an illustration of the use
of imaging and computational tools to brain imaging research. This work
includes comparison of functional, structural, and molecular imaging
techniques as well as exploration of the temporal dynamics across networks
in the brain. Recently, our explorations of these multiple data types have
converged to suggest a new hypothesis about the origins of Alzheimer's
disease that begins with brain activity and metabolism patterns in healthy
young adults that then triggers a molecular cascade leading to tissue loss
and clinical impairment in advanced aging.
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