Static and dynamic methods for the analysis of biological networks
Speaker: Ron Y. Pinter , Dept. of Comp. Sci., Technion - Israel Institute of Technology
Date: July 19 2006
Time: 3:00PM
Location: TOC Lab
Host: Bonnie Berger, MIT
Contact: Kathleen Dickey, 617 253 3037, kvdickey@mit.edu
Relevant URL: Abstract: Elucidating the behavior of biological networks requires the development and the application of computational tools and techniques. Naturally, different methods are suitable for different kinds of analyses, e.g. extracting qualitative vs. observing quantitative properties, employing discrete vs. continuous modeling, and utilizing static vs. dynamic analysis. Specifically, methods that are static in nature extract structural and semantic properties from the description of a network or a pathway, whereas dynamic methods aim at understanding and predicting the functional characteristics of a network's or a pathway's behavior. In this talk I will present tools and techniques that we have devised recently to (1) align and compare metabolic pathways, and (2) analyze the transient behavior of regulatory networks, along with the biological consequences that they have yielded. I will conclude with some thoughts concerning the potential integration of the methods into a unified framework so as to fit the end-users' needs.
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