CSAIL Event Calendar: Previous Series
Human Genome Variation and Risk to Common Disease
Speaker: Paul de Bakker , Massachusetts General Hospital, Dept of Molecular Biology
Relevant URL: http://www-math.mit.edu/compbiosem/
With the recent completion of the International HapMap Project and the availability of high-throughput genotyping technologies, it has now become possible to comprehensively test common genetic variation for a etiological role in complex traits and common disease. The HapMap provides insight into the fine-scale patterns of linkage disequilibrium, haplotype block structure, and hotspots of recombination. I will describe computational strategies to association testing through linkage disequilibrium on a genome-wide scale. Given that HapMap is based only 270 individuals from four populations, it is essential that we evaluate how well the observed LD structure in HapMap will transfer across different population samples. I will present empirical data that support the efficacy of HapMap in genome-wide association studies.