RNA conformational switches and the Fast Fourier Transform
Speaker: Peter Clote, BC
Date: Wednesday, February 27 2013
Time: 11:30AM to 1:00PM
Location: Stata Center 32-G575
Host: Bonnie Berger, MIT
Contact: Patrice Macaluso, firstname.lastname@example.orgRelevant URL:
RNA secondary structure forms a scaffold for tertiary structure formation,hence is a major determinant for both structure and function of an RNA molecule. While protein secondary structure is predicted by machine learning methods, RNA secondary structure can be predicted by dynamic programming methods that use an ab initio energy model will experimentally measured free energy parameters. Such thermodynamics-based methods constitute important tools especially when confronted with novel RNAs of unknown function.